Related Experiment Video

Updated: Sep 25, 2025

Screening and Identification of Small Peptides Targeting Fibroblast Growth Factor Receptor2 using a Phage Display Peptide Library
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Screening and Identification of Small Peptides Targeting Fibroblast Growth Factor Receptor2 using a Phage Display Peptide Library

Published on: September 30, 2019

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Signaling Pathway and Small-Molecule Drug Discovery of FGFR: A Comprehensive Review

Jia Zheng1, Wei Zhang1, Linfeng Li1

  • 1Center for Novel Target and Therapeutic Intervention, Institute of Life Sciences, Chongqing Medical University, Chongqing, China.

Frontiers in Chemistry
|May 2, 2022
PubMed

Insights

Targeted cancer therapy innovations include fibroblast growth factor receptor (FGFR) inhibitors. This review details FGFR signaling, inhibitor types, and future perspectives for novel targeted therapies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • Fibroblast growth factor receptors (FGFRs) are key targets in cancer therapy.
  • FGFRs are receptor tyrosine kinases with critical biological roles.
  • Aberrant FGFR signaling is common in various tumors.

Purpose of the Study:

  • To review the biological basis of FGF/FGFR signaling.
  • To categorize small-molecule FGFR inhibitors by mechanism of action.
  • To provide an overview of small-molecule-based FGFR therapies and future directions.

Main Methods:

  • Literature review of FGF/FGFR signaling pathways.
  • Classification of FGFR inhibitors based on their modes of action.
  • Systematic analysis of small-molecule therapies targeting FGFR.

Main Results:

  • Detailed explanation of FGF/FGFR signaling pathways.
  • Categorization of multiple generations of FGFR kinase inhibitors.
  • Overview of diverse small-molecule-based therapeutic modalities.

Conclusions:

  • FGFRs represent a significant target for innovative cancer treatments.
  • Small-molecule inhibitors offer a promising avenue for targeted therapy.
  • Further development of novel FGFR inhibitors is essential for advancing cancer care.
Keywords:
FGFRcancersmall-molecule inhibitorstargeted therapytyrosine kinase

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