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Updated: Aug 19, 2026

Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria
Published on: May 8, 2013
Rapid SERS identification of methicillin-susceptible and methicillin-resistant Staphylococcus aureus via aptamer
Shu Wang1,2, Hao Dong1,2, Wanzhu Shen3
1Hefei Institute of Physical Science, Chinese Academy of Sciences Hefei 230036 P. R China zhanglong@aiofm.ac.cn.
Abstract:
Here, we report a label-free surface-enhanced Raman scattering (SERS) method for the rapid and accurate identification of methicillin-susceptible Staphylococcus aureus (MSSA) and methicillin-resistant Staphylococcus aureus (MRSA) based on aptamer-guided AgNP enhancement and convolutional neural network (CNN) classification. Sixty clinical isolates of Staphylococcus aureus (S. aureus), comprising 30 strains of MSSA and 30 strains of MRSA were used to build the CNN classification model. The developed method exhibited 100% identification accuracy for MSSA and MRSA, and is thus a promising tool for the rapid detection of drug-sensitive and drug-resistant bacterial strains.
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