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Does Insufficient Sleep Increase the Risk of Developing Insulin Resistance: A Systematic Review
Trisha Singh1, Tarig H Ahmed1, Nusyba Mohamed1
1Internal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.
Cureus
|May 2, 2022
Summary
Adults need at least seven hours of sleep for health. Insufficient sleep is linked to insulin resistance, potentially increasing type-2 diabetes risk.
Area of Science:
- Metabolic Health
- Sleep Science
- Endocrinology
Background:
- Adults require a minimum of seven hours of sleep nightly for optimal health.
- Sleep deprivation is a prevalent issue in the adult population, often linked to modern lifestyle stressors.
- Understanding the connection between reduced sleep and metabolic dysfunction is crucial for public health.
Purpose of the Study:
- To investigate the impact of reduced sleep duration on the development of insulin resistance.
- To explore the potential underlying mechanisms that link sleep deprivation and insulin resistance.
Main Methods:
- Systematic literature review using databases such as PubMed, PubMed Central (PMC), and MEDLINE.
- Inclusion/exclusion criteria applied to titles and abstracts, followed by quality appraisal.
- Review of ten rigorously selected studies examining sleep duration and metabolic markers.
Main Results:
- A significant association was found between short sleep duration and the development of insulin resistance.
- Inflammatory markers (C-reactive protein, serum amyloid A), biomarkers (glucagon-like peptide-1), and circadian misalignment emerged as potential contributing factors.
- Short sleep duration is linked to metabolic complications, including an increased risk of type-2 diabetes.
Conclusions:
- Adequate sleep, defined as more than seven hours per night, is essential for preventing metabolic complications like type-2 diabetes in adults.
- The relationship between sleep deprivation and insulin resistance is complex and multifactorial.
- Further research is necessary to fully elucidate the intricate mechanisms underlying this association.
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