Related Experiment Video
Updated: Sep 25, 2025

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
Synthesis of new N,N'-Pd(Pt) complexes based on sulfanyl pyrazoles, and investigation of their in vitro anticancer
Vnira R Akhmetova1, Nail S Akhmadiev1, Marat F Abdullin2
1Institute of Petrochemistry and Catalysis, Russian Academy of Sciences 141 Prospekt Oktyabrya 450075 Ufa Russian Federation vnirara@mail.ru +7 3472 842750 +7 3472 842750.
Abstract:
The synthesis of new N,N'-mononuclear bi-ligand Pd(ii) and tri-ligand Pt(ii)complexes bearing sulfanyl(phenyl, benzyl, cyclohexyl, 4-hydroxyphenyl)3,5-dimethyl-1H-pyrazole ligands has been carried out. The obtained compounds were studied for apoptosis-inducing activity and effect on the cell cycle for Jurkat, K562, and U937 neoplastic cell cultures and conditionally normal human embryonic kidney HEK293 cells. The cells showed the highest sensitivity to platinum and palladium complexes in comparison with ligands and cisplatin. The cytotoxic properties are enhanced for compounds with cyclohexyl substituents at the S-atom in sulfanyl pyrazoles and complexes.
Related Concept Videos
Aryldiazonium Salts to Azo Dyes: Diazo Coupling
Preparation and Reactions of Sulfides

