Clinical aspects of phencyclidine (PCP)

Area of Science:

• Neuroscience
• Psychiatry
• Pharmacology

Background:

• Phencyclidine (PCP) is a dissociative anesthetic with a history of recreational abuse.
• PCP abuse presents significant challenges in clinical diagnosis and management.
• Understanding the multifaceted nature of PCP is crucial for effective intervention.

Purpose of the Study:

• To conduct a comprehensive review of the existing phencyclidine literature.
• To explore the historical context, clinical manifestations, diagnostic standards, and therapeutic strategies for PCP abuse.
• To synthesize current knowledge on PCP for researchers and clinicians.

Main Methods:

• Literature review methodology.
• Systematic search of scientific databases for phencyclidine-related studies.
• Analysis and synthesis of 71 cited references.

Main Results:

• Detailed historical overview of phencyclidine's emergence and use.
• Elucidation of the diverse clinical effects associated with PCP intoxication.
• Summary of established diagnostic criteria for PCP abuse and dependence.
• Overview of current treatment modalities and approaches for PCP-related disorders.

Conclusions:

• Phencyclidine abuse remains a significant public health concern requiring ongoing research and clinical attention.
• A thorough understanding of PCP's history, effects, diagnosis, and treatment is essential for healthcare professionals.
• This review consolidates key information to guide future research and clinical practice in managing PCP abuse.