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Updated: Sep 25, 2025
Author Spotlight: High-Quality Quantum Dot Nanobeads for Sensitive Fluorescent Lateral Flow Immunoassays
Published on: June 28, 2024
Polyethyleneimine-interlayered silica-core quantum dot-shell nanocomposites for sensitive detection of Salmonella
Bo Zhang1,2, Xingsheng Yang3,4, Xiaoxian Liu3,4
1School of Public Health, Jilin University Changchun 130021 PR China li_juan@jlu.edu.cn.
Abstract:
Herein, we synthesized high-performance SiO2-core quantum dot (QD)-shell nanocomposites (SiO2@PEI-QDs) using the polyethyleneimine (PEI)-mediated adsorption method. Cationic PEI was used to form a positively charged interlayer on the SiO2 core, which achieved a dense adsorption of carboxylated QDs to form a shell of QDs and maintained a good dispersibility of the nanocomposite. The SiO2@PEI-QDs showed excellent stability and high luminescence, and served as high-performance fluorescent labels for the detection of bacteria when used with the lateral flow immunoassay (LFA) technique. An SiO2@PEI-QD-based LFA strip was successfully applied to rapidly detect Salmonella typhimurium in milk samples with a low limit of 5 × 102 cells per mL.
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