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Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Angle Closure Glaucoma: Treatment01:28

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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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Open Angle Glaucoma: Treatment01:27

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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
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Pleural Effusion Overview
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Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

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Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
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Related Experiment Video

Updated: Sep 25, 2025

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
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Ocular involvement in TEMPI syndrome.

Jo-Hsuan Wu1, Narine Viruni2, Justin Chun3

  • 1Shiley Eye Institute and Viterbi Family Department of Ophthalmology, University of California, San Diego, CA, 92093, USA.

American Journal of Ophthalmology Case Reports
|May 2, 2022
PubMed
Summary
This summary is machine-generated.

This study details the first reported ocular complications in TEMPI syndrome, a rare condition. Findings highlight retinal vascular changes and vision loss, emphasizing the need for ophthalmological screening in affected patients.

Keywords:
Macular edemaRetinal ischemiaTEMPI syndrome

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Area of Science:

  • Ophthalmology
  • Hematology
  • Rare Diseases

Background:

  • TEMPI syndrome is a rare multisystem disorder characterized by telangiectasias, elevated erythropoietin with erythrocytosis, monoclonal gammopathy, perinephric fluid collections, and intrapulmonary shunting.
  • Ocular manifestations of TEMPI syndrome have not been previously documented.

Observation:

  • A 64-year-old male patient with known TEMPI syndrome presented with bilateral, painless vision loss.
  • Ophthalmological examination revealed chronic retinal ischemia, microvascular damage, and fluctuating cystoid macular edema.

Findings:

  • The observed retinal vascular changes are likely linked to chronic systemic hypoxemia associated with TEMPI syndrome.
  • Cystoid macular edema may be related to bortezomib treatment, a therapy used for monoclonal gammopathy.

Implications:

  • This case highlights the potential for significant ocular pathology in patients with TEMPI syndrome.
  • Comprehensive ophthalmological evaluations are recommended for early detection and management of visual complications in TEMPI syndrome patients.