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Shared acute phase traits in effector and memory human CD8 T cells.

Silvia A Fuertes Marraco1, Daniel Alpern2, Sébastien Lofek1

  • 1Department of Oncology, Lausanne University Hospital and University of Lausanne, Epalinges, Switzerland.

Current Research in Immunology
|May 2, 2022
PubMed
Summary
This summary is machine-generated.

Human CD8 T cells show shared "acute traits" across differentiation states during yellow fever vaccination. This highlights the need to distinguish differentiation states in acute immune responses.

Keywords:
Acute traitsEffectorHuman CD8 T cellsMemoryYF-17D vaccination

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Area of Science:

  • Immunology
  • Cellular Biology
  • Virology

Background:

  • CD8 T cells are crucial for immune protection, with diverse effector and memory subsets.
  • Human studies often miss the acute infection phase, limiting understanding of early T cell heterogeneity.
  • Yellow fever vaccination provides a model for studying human immune responses to acute viral infection.

Purpose of the Study:

  • To analyze the human CD8 T cell response during acute viral infection using yellow fever vaccination.
  • To identify shared characteristics across different CD8 T cell subsets during the peak immune response.
  • To investigate the differentiation states of CD8 T cells in the early phase of an immune response.

Main Methods:

  • Flow cytometry analysis of 21 markers on human CD8 T cells.
  • Assessment of differentiation, activation, cycling, and effector functions.
  • Single-cell chromatin accessibility analysis.

Main Results:

  • Distinct 'acute traits' were observed in all non-naïve CD8 T cell subsets at the peak response.
  • These traits include low BCL-2, high KI67, CD38, HLA-DR, Granzyme B, and Perforin.
  • Memory and effector-differentiated CD8 T cells clustered together during the acute phase.

Conclusions:

  • Shared 'acute traits' exist across CD8 T cell differentiation subsets during an acute immune response.
  • It is crucial to differentiate CD8 T cell states when studying acute human immune responses.
  • This study refines our understanding of CD8 T cell heterogeneity in early viral infection responses.