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Orexin Signaling: A Complex, Multifaceted Process
Natasha C Dale1,2,3, Daniel Hoyer4,5,6, Laura H Jacobson4,5,7
1Molecular Endocrinology and Pharmacology, Harry Perkins Institute of Medical Research and Centre for Medical Research, The University of Western Australia, Nedlands, WA, Australia.
Frontiers in Cellular Neuroscience
|May 2, 2022
Summary
The orexin system
Area of Science:
- Neuroscience
- Pharmacology
- Molecular Biology
Background:
- The orexin system involves two G protein-coupled receptors (OX1R, OX2R) and two agonists (orexin-A, orexin-B).
- Orexin receptor signaling is known to be diverse and context-dependent.
Purpose of the Study:
- To discuss the early signal transduction interactions of orexin receptors.
- To emphasize the direct G protein interactions of OX1R and OX2R.
Main Methods:
- Review of early signal transduction events.
- Focus on direct G protein interactions.
Main Results:
- Orexin receptor coupling is highly diverse, varying by tissue, cell type, and context.
- Ligands, receptor-protein interactions, and cellular environment critically influence G protein coupling profiles.
Conclusions:
- Understanding orexin receptor G protein coupling is crucial for elucidating orexin system function in vivo.
- This knowledge can guide the development of novel therapeutics targeting the orexin system.
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