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Related Experiment Video

Updated: Sep 25, 2025

Optogenetic Manipulation of Neural Circuits During Monitoring Sleep/wakefulness States in Mice
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Orexin Signaling: A Complex, Multifaceted Process.

Natasha C Dale1,2,3, Daniel Hoyer4,5,6, Laura H Jacobson4,5,7

  • 1Molecular Endocrinology and Pharmacology, Harry Perkins Institute of Medical Research and Centre for Medical Research, The University of Western Australia, Nedlands, WA, Australia.

Frontiers in Cellular Neuroscience
|May 2, 2022
PubMed
Summary
This summary is machine-generated.

The orexin system

Keywords:
G proteinGPCR (G protein coupled receptor)arrestinorexinorexin 1 receptororexin 2 receptorsignaling

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Related Experiment Videos

Last Updated: Sep 25, 2025

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Molecular Biology

Background:

  • The orexin system involves two G protein-coupled receptors (OX1R, OX2R) and two agonists (orexin-A, orexin-B).
  • Orexin receptor signaling is known to be diverse and context-dependent.

Purpose of the Study:

  • To discuss the early signal transduction interactions of orexin receptors.
  • To emphasize the direct G protein interactions of OX1R and OX2R.

Main Methods:

  • Review of early signal transduction events.
  • Focus on direct G protein interactions.

Main Results:

  • Orexin receptor coupling is highly diverse, varying by tissue, cell type, and context.
  • Ligands, receptor-protein interactions, and cellular environment critically influence G protein coupling profiles.

Conclusions:

  • Understanding orexin receptor G protein coupling is crucial for elucidating orexin system function in vivo.
  • This knowledge can guide the development of novel therapeutics targeting the orexin system.