Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Molecular Feasibility of Gene Sequencing on Lymph Node Fine-Needle Cytology Samples of Non-Hodgkin Lymphoma.

International journal of molecular sciences·2026
Same author

Pathological complete response in a POLE-mutated non-small cell lung cancer patient treated with perioperative chemoimmunotherapy: a case report and review of the literature.

MedScience·2026
Same author

New Paradigm in Ocular Surface Squamous Neoplasia-Insights from a Case Report on the Use of Interferon in Treatment.

Oncology research·2026
Same author

Virtual Evaluation of Hematoxylin & Eosin via Digital Pathology Survey (VEED) Project: Results from a Non-Inferiority Study of a Tabs-Based Staining Method.

Diagnostics (Basel, Switzerland)·2026
Same author

Cytopathology Terminology Systems: European Federation of Cytological Societies Survey on Practice in Europe.

Cytopathology : official journal of the British Society for Clinical Cytology·2026
Same author

Role of ancillary techniques in the WHO classification of lymph node fine-needle cytology.

Journal of the American Society of Cytopathology·2026

Related Experiment Video

Updated: Sep 25, 2025

Detection of Residual Donor Erythroid Progenitor Cells after Hematopoietic Stem Cell Transplantation for Patients with Hemoglobinopathies
11:59

Detection of Residual Donor Erythroid Progenitor Cells after Hematopoietic Stem Cell Transplantation for Patients with Hemoglobinopathies

Published on: September 6, 2017

7.5K

Observations on hematogones with light chain restriction.

Angela D'Ardia1, Valeria Ciliberti1, Pio Zeppa1

  • 1University of Salerno - Baronissi Campus: Universita degli Studi di Salerno, Campus Baronissi Via Allende Baronissi (SA), Salerno, Italy.

Leukemia Research Reports
|May 2, 2022
PubMed
Summary

Light-chain restricted hematogones (LCR HGs) can mimic B-cell lymphoma in lymph nodes. Additional criteria are needed for accurate lymphoma diagnosis in these cases.

Keywords:
Light chain restrictionReactive processes

More Related Videos

Phenotypic Analysis and Isolation of Murine Hematopoietic Stem Cells and Lineage-committed Progenitors
12:03

Phenotypic Analysis and Isolation of Murine Hematopoietic Stem Cells and Lineage-committed Progenitors

Published on: July 8, 2012

18.9K
Comprehensive Protocol to Sample and Process Bone Marrow for Measuring Measurable Residual Disease and Leukemic Stem Cells in Acute Myeloid Leukemia
09:57

Comprehensive Protocol to Sample and Process Bone Marrow for Measuring Measurable Residual Disease and Leukemic Stem Cells in Acute Myeloid Leukemia

Published on: March 5, 2018

29.7K

Related Experiment Videos

Last Updated: Sep 25, 2025

Detection of Residual Donor Erythroid Progenitor Cells after Hematopoietic Stem Cell Transplantation for Patients with Hemoglobinopathies
11:59

Detection of Residual Donor Erythroid Progenitor Cells after Hematopoietic Stem Cell Transplantation for Patients with Hemoglobinopathies

Published on: September 6, 2017

7.5K
Phenotypic Analysis and Isolation of Murine Hematopoietic Stem Cells and Lineage-committed Progenitors
12:03

Phenotypic Analysis and Isolation of Murine Hematopoietic Stem Cells and Lineage-committed Progenitors

Published on: July 8, 2012

18.9K
Comprehensive Protocol to Sample and Process Bone Marrow for Measuring Measurable Residual Disease and Leukemic Stem Cells in Acute Myeloid Leukemia
09:57

Comprehensive Protocol to Sample and Process Bone Marrow for Measuring Measurable Residual Disease and Leukemic Stem Cells in Acute Myeloid Leukemia

Published on: March 5, 2018

29.7K

Area of Science:

  • Hematology
  • Oncology
  • Immunology

Background:

  • Light-chain restricted hematogones (LCR HGs) are normally found in bone marrow.
  • LCR HGs can be detected by flow cytometry (FC).
  • LCR HGs can mimic B-cell lymphoma, posing a diagnostic challenge.

Purpose of the Study:

  • To highlight the diagnostic pitfall of LCR HGs in lymph nodes.
  • To recommend additional criteria for lymphoma diagnosis when LCR HGs are present.

Main Methods:

  • Flow cytometry (FC) for detection of LCR HGs.
  • Morphological, phenotypical, and molecular analyses.

Main Results:

  • LCR HGs can occur in lymph nodes, not just bone marrow.
  • The presence of LCR HGs can be mistaken for B-cell lymphoma.
  • This misdiagnosis can negatively impact patient management.

Conclusions:

  • LCR HGs in lymph nodes require careful evaluation.
  • Additional diagnostic criteria are essential for accurate lymphoma diagnosis in the presence of LCR HGs.
  • Utilizing morphological, phenotypical, or molecular methods alongside FC is recommended for definitive lymphoma diagnosis.