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Hematological indices and their correlation with glucose control parameters in a prediabetic rat model
Desak Gede Budi Krisnamurti1, Erni H Purwaningsih2, Tri Juli Edi Tarigan3
1Doctoral Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
Veterinary World
|May 2, 2022
Summary
Prediabetes significantly alters hematological parameters in rats, with decreased red blood cells and increased platelets. These changes correlate with blood glucose levels, offering insights into glycemic control.
Area of Science:
- Endocrinology
- Hematology
- Metabolic Disorders
Background:
- Chronic hyperglycemia in prediabetes can lead to systemic disruptions, including alterations in hematological parameters.
- Understanding these changes is crucial for predicting diabetes progression.
Purpose of the Study:
- To investigate the correlation between prediabetes and hematological indices.
- To establish a prediabetic rat model for studying these correlations.
Main Methods:
- Prediabetes was induced in male rats using a high-fat, high-glucose diet and streptozotocin (STZ).
- Fasting blood glucose (FBG), insulin, and glycated albumin levels were measured.
- Hematological parameters including red blood cells, hemoglobin, hematocrit, white blood cells, and platelets were analyzed.
Main Results:
- Prediabetic rats showed significantly increased FBG and insulin levels compared to controls.
- A decrease in red blood cells, hemoglobin, and hematocrit was observed in prediabetic rats.
- Platelet count significantly increased, while white blood cell count showed a negative correlation with glycated albumin.
Conclusions:
- Significant correlations exist between hematological parameters and prediabetes in the rat model.
- Hematological indices can serve as valuable indicators for monitoring glycemic control in prediabetic states.
