Related Experiment Video

Updated: Sep 25, 2025

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

10.6K

Impact of the caFFR-Guided Functional SYNTAX Score on Ventricular Tachycardia/Fibrillation Development in Patients

Jiazhi Pan1, Qiuxia Zhang1, Li Lei1

  • 1Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Frontiers in Cardiovascular Medicine
|May 2, 2022
PubMed

Insights

The functional SYNTAX score (FSScaFFR) better predicts ventricular tachycardia/fibrillation (VT/VF) after acute myocardial infarction (AMI) than the standard SYNTAX score. FSScaFFR is an independent predictor of VT/VF in AMI patients.

Area of Science:

  • Cardiology
  • Interventional Cardiology
  • Cardiac Electrophysiology

Background:

  • Acute myocardial infarction (AMI) is a critical condition often associated with life-threatening arrhythmias.
  • Ventricular tachycardia/ventricular fibrillation (VT/VF) poses a significant risk to patients post-AMI.
  • Assessing coronary artery disease (CAD) severity is crucial for risk stratification in AMI patients.

Purpose of the Study:

  • To investigate the association between coronary artery disease (CAD) severity and the occurrence of VT/VF in patients following AMI.
  • To compare the predictive value of the SYNTAX score (SS) and the functional SYNTAX score derived from fractional flow reserve (FSScaFFR) for VT/VF post-AMI.

Main Methods:

  • Retrospective analysis of 705 patients with AMI who underwent percutaneous coronary intervention (PCI).
  • Logistic regression and backward stepwise analysis to identify correlation factors for VT/VF.
  • Receiver operating characteristic (ROC) curve analysis to evaluate the discriminative power of SS and FSScaFFR for incident VT/VF.

Main Results:

  • Approximately 8.2% of patients experienced VT/VF.
  • FSScaFFR was identified as an independent predictor of VT/VF post-AMI (OR: 1.155; p=0.004).
  • ROC analysis demonstrated that FSScaFFR had significantly better discriminative power for VT/VF compared to SS (0.759 vs. 0.695, p<0.0001).

Conclusions:

  • Incident VT/VF in AMI patients is strongly linked to CAD severity, as assessed by SS and FSScaFFR.
  • FSScaFFR exhibits a higher correlation with VT/VF occurrence compared to SS.
  • FSScaFFR is a significant independent predictor of both early and late VT/VF events following AMI.
Abstract

Keywords:
acute myocardial infarctioncaFFRfunctional SYNTAX scoreventricular fibrillationventricular tachycardia

More Related Videos

A Model of Long-Term Ventricular Fibrillation in Isolated Rat Hearts07:56

A Model of Long-Term Ventricular Fibrillation in Isolated Rat Hearts

Published on: February 17, 2023

1.0K
Real-Time Cardiac Mapping with a Noninvasive Imageless Electrocardiographic Imaging System10:17

Real-Time Cardiac Mapping with a Noninvasive Imageless Electrocardiographic Imaging System

Published on: April 11, 2025

990

Related Concept Videos

ECG Interpretation of Arrhythmias II: Atrial, Junctional and Ventricular Arrhythmias01:25

ECG Interpretation of Arrhythmias II: Atrial, Junctional and Ventricular Arrhythmias

Arrhythmia is a condition characterized by an irregular heart rhythm, with ECG changes that differ based on its origin and nature. The types of arrhythmias discussed below include atrial, junctional, and ventricular arrhythmias.Atrial ArrhythmiasPremature Atrial Complexes (PACs): PACs are early atrial beats caused by stress, caffeine, alcohol, electrolyte imbalances, hypoxia, hyperthyroidism, or certain medications (e.g., bronchodilators and decongestants). The ECG shows early P waves with an...
181
Dysrhythmias III: Characteristics of Dysrhythmias01:29

Dysrhythmias III: Characteristics of Dysrhythmias

Dysrhythmias, also known as arrhythmias, are irregular heart rhythms that result from abnormal electrical activity in the heart, affecting its ability to circulate blood efficiently. Tachyarrhythmias, a subset of dysrhythmias, are characterized by abnormally fast heart rates exceeding 100 beats per minute. Here are some types of tachyarrhythmias with their distinct ECG features:Sinus Tachycardia:Sinus tachycardia presents a regular heart rhythm with an increased rate of 101-180 beats per...
133
Disturbances in Heart Rhythm01:29

Disturbances in Heart Rhythm

Arrhythmia or dysrhythmia refers to an abnormal heart rhythm caused by a defect in the heart's conduction system. It can cause the heart to beat irregularly, too quickly, or too slowly, leading to symptoms like chest pain, shortness of breath, and fainting. Factors such as stress, caffeine, alcohol, nicotine, cocaine, certain drugs, congenital defects, diseases, and electrolyte abnormalities can trigger arrhythmias.
Arrhythmias are categorized by their speed, rhythm, and origin. A slow heart...
1.3K
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
31
Dysrhythmias II: Classification of Tachyarrhythmias01:28

Dysrhythmias II: Classification of Tachyarrhythmias

Tachyarrhythmias are a type of dysrhythmia where the heart rate exceeds 100 beats per minute. Here are some common types of tachyarrhythmias:Sinus TachycardiaSinus tachycardia originates from increased impulses from the sinus node, leading to an elevated heart rate. It is often triggered by stress, fever, or exercise.Patients may experience palpitations, a sensation of a racing heart, dizziness, and chest discomfort.Causes and Risk Factors: Common causes include physical exertion, emotional...
144
Dysrhythmias VI: Management of Dysrhythmias01:25

Dysrhythmias VI: Management of Dysrhythmias

Dysrhythmia management involves a multifaceted approach, incorporating pharmacological treatments, medical procedures, surgical interventions, lifestyle modifications, and patient education.Pharmacological ManagementAntiarrhythmic Drugs:Class I (Sodium Channel Blockers): This class includes quinidine and procainamide, which reduce the speed of impulse conduction in the heart, stabilize the cardiac membrane, and control arrhythmias. Quinidine and procainamide are Class IA agents that prolong the...
123