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Preparation of Mitochondria from Ovarian Cancer Tissues and Control Ovarian Tissues for Quantitative Proteomics Analysis
Published on: November 18, 2019
Mitochondrial Dysfunction Pathway Alterations Offer Potential Biomarkers and Therapeutic Targets for Ovarian Cancer
Liang Shen1,2, Xianquan Zhan1,2,3
1Department of Gynecology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, 324 Jingwu Weiqi Road, Jinan, Shandong 250021, China.
Abstract:
The mitochondrion is a very versatile organelle that participates in some important cancer-associated biological processes, including energy metabolism, oxidative stress, mitochondrial DNA (mtDNA) mutation, cell apoptosis, mitochondria-nuclear communication, dynamics, autophagy, calcium overload, immunity, and drug resistance in ovarian cancer. Multiomics studies have found that mitochondrial dysfunction, oxidative stress, and apoptosis signaling pathways act in human ovarian cancer, which demonstrates that mitochondria play critical roles in ovarian cancer. Many molecular targeted drugs have been developed against mitochondrial dysfunction pathways in ovarian cancer, including olive leaf extract, nilotinib, salinomycin, Sambucus nigra agglutinin, tigecycline, and eupatilin. This review article focuses on the underlying biological roles of mitochondrial dysfunction in ovarian cancer progression based on omics data, potential molecular relationship between mitochondrial dysfunction and oxidative stress, and future perspectives of promising biomarkers and therapeutic targets based on the mitochondrial dysfunction pathway for ovarian cancer.
Insights
Mitochondrial dysfunction is key in ovarian cancer, impacting processes like metabolism and apoptosis. Targeting these pathways offers new therapeutic strategies for ovarian cancer treatment.
Area of Science:
- Mitochondrial biology
- Oncology
- Molecular medicine
Background:
- Mitochondria are crucial organelles involved in numerous cancer-associated processes.
- Mitochondrial dysfunction, oxidative stress, and apoptosis are implicated in human ovarian cancer.
- Omics data highlight the critical roles of mitochondria in ovarian cancer progression.
Purpose of the Study:
- To review the biological roles of mitochondrial dysfunction in ovarian cancer.
- To explore the link between mitochondrial dysfunction and oxidative stress.
- To identify potential biomarkers and therapeutic targets in ovarian cancer.
Main Methods:
- Literature review of omics data.
- Analysis of molecular mechanisms.
- Synthesis of current research on mitochondrial dysfunction in ovarian cancer.
Main Results:
- Mitochondrial dysfunction influences energy metabolism, oxidative stress, apoptosis, and drug resistance in ovarian cancer.
- Specific molecular targeted drugs show potential against mitochondrial dysfunction pathways.
- Omics studies confirm the significance of mitochondrial pathways in ovarian cancer.
Conclusions:
- Mitochondrial dysfunction is a central driver of ovarian cancer progression.
- Targeting mitochondrial pathways presents a promising avenue for novel ovarian cancer therapies.
- Further research into mitochondrial biomarkers and drug targets is warranted.
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