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Related Experiment Video

Updated: Sep 25, 2025

Assembly and Operation of an Acoustofluidic Device for Enhanced Delivery of Molecular Compounds to Cells

Assembly and Operation of an Acoustofluidic Device for Enhanced Delivery of Molecular Compounds to Cells

Published on: January 21, 2021

Acoustofluidics for simultaneous nanoparticle-based drug loading and exosome encapsulation.

Zeyu Wang¹, Joseph Rich², Nanjing Hao¹

¹Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC 27708 USA.

Microsystems & Nanoengineering

|May 2, 2022

Summary

A novel acoustofluidic device rapidly loads drugs into nanocarriers and encapsulates them within exosomes. This hybrid nanocarrier system enhances drug delivery efficiency and tumor cell inhibition.

Keywords:

Microfluidics Nanofabrication and nanopatterning

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Last Updated: Sep 25, 2025

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Published on: March 6, 2016

Area of Science:

Biomedical Engineering
Nanotechnology
Drug Delivery

Background:

Exosome and nanocarrier encapsulation improves targeted drug delivery efficacy and reduces side effects.
Current methods for exosome-encapsulated nanocarriers suffer from low drug loading and complex processes.

Purpose of the Study:

To develop an acoustofluidic device for simultaneous drug loading and exosome encapsulation.
To improve drug loading efficiency and simplify the production of exosome-encapsulated nanocarriers.

Main Methods:

Utilized an acoustofluidic device leveraging acoustic radiation force, microstreaming, and shear stress.
Achieved concentration and fusion of exosomes, drugs, and porous silica nanoparticles in a rotating droplet.
Developed a rapid, minutes-long process without chemical modification.

Main Results:

Created drug-loaded silica nanocarriers encased in exosomal membranes.
Achieved nearly 30% drug loading efficiency for molecules like doxorubicin.
Demonstrated efficient intracellular transport and significant inhibition of tumor cell proliferation.

Conclusions:

The acoustofluidic platform enables rapid, efficient production of hybrid exosome-encapsulated nanocarriers.
This technology offers a promising approach to advance drug delivery research and applications.
Physical forces can be harnessed for innovative nanocarrier generation.