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Related Experiment Video

Updated: Sep 25, 2025

Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients

Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients

Published on: April 14, 2014

Pain Symptoms in Optic Neuritis.

Xiayin Yang^1,2, Xuefen Li^3,4, Mengying Lai^4,5

¹School of Optometry, The Hong Kong Polytechnic University, Kowloon, Hong Kong SAR, China.

Frontiers in Pain Research (Lausanne, Switzerland)

|May 2, 2022

Summary

Optic neuritis (ON), an autoimmune CNS disorder, presents with varied symptoms, notably pain. This review examines pain in ON related to multiple sclerosis, NMOSD, and MOGAD, aiding diagnosis and management.

Keywords:

mechanism multiple sclerosis myelin oligodendrocyte glycoprotein associated disease neuromyelitis optica spectrum disorder optic neuritis pain treatment

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Last Updated: Sep 25, 2025

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Published on: September 13, 2024

Area of Science:

Neuroimmunology
Ophthalmology
Neurology

Background:

Optic neuritis (ON) is an autoimmune disorder affecting the central nervous system (CNS).
Clinical presentation and symptoms of ON can vary significantly among patients.
Pain is a frequently reported symptom in ON, often prompting medical consultation.

Purpose of the Study:

To review the occurrence of pain in ON across different underlying conditions.
To explore pathophysiological explanations for pain in ON.
To aid in the differential diagnosis of ON, particularly during disease onset.

Main Methods:

Literature review of studies on optic neuritis and associated pain.
Analysis of pain symptoms in the context of multiple sclerosis (MS), neuromyelitis optica spectrum disorder (NMOSD), and myelin oligodendrocyte glycoprotein associated disease (MOGAD).
Synthesis of information regarding diagnostic approaches and follow-up recommendations.

Main Results:

Pain is a common and significant symptom in optic neuritis.
The characteristics and prevalence of pain may differ based on the specific underlying autoimmune disorder (MS, NMOSD, MOGAD).
Understanding pain patterns can assist in differentiating ON subtypes and guiding diagnostic workups.

Conclusions:

Pain assessment is crucial in the evaluation of optic neuritis.
Differential diagnosis of ON can be improved by considering pain characteristics in relation to underlying conditions.
Recommendations are provided for physicians to guide diagnostic decisions and patient management in ON.