Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

5.5K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
5.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of improved water, sanitation, handwashing, and nutrition on early childhood IgG immune repertoire development against <i>Shigella</i> and enteroinvasive <i>Escherichia coli</i> (EIEC).

mSphere·2026
Same author

Prevalence of a Composite Outcome to Capture Child and Liver Health One Year After Pediatric Liver Transplantation in the Starzl Network.

Pediatric transplantation·2026
Same author

A network meta-analysis comparing laparoscopic, open and robotic restorative proctocolectomy with ileal pouch-anal anastomosis [IPAA].

Updates in surgery·2026
Same author

Investigating the shared genetic architecture between selective immunoglobulin A deficiency and autoimmune diseases.

Human genetics·2026
Same author

Healthcare resources for inborn errors of immunity in the Asia-Pacific region.

Journal of human immunity·2026
Same author

Variability in the TLR3 type I interferon pathway is predictive of RNA vaccine responses.

Science advances·2026

Related Experiment Video

Updated: Sep 25, 2025

Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts
07:18

Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts

Published on: June 13, 2019

7.1K

Fatal SARS in X-Linked Lymphoproliferative Disease Type 1: A Case Report.

Ming Hin Chung1, Gilbert T Chua2, Daniel Leung2

  • 1Department of Pediatrics and Adolescent Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong SAR, China.

Frontiers in Pediatrics
|May 2, 2022
PubMed
Summary

X-linked lymphoproliferative disease (XLP1) can cause severe immune dysregulation. Children with severe COVID-19 should be evaluated for underlying inborn errors of immunity (IEI) like XLP1.

Keywords:
COVID-19X-linked lymphoproliferative disease type 1 (XLP1)agammaglobulinemiainborn error of immunitysevere acute respiratory syndrome (SARS)

More Related Videos

From a 2DE-Gel Spot to Protein Function: Lesson Learned From HS1 in Chronic Lymphocytic Leukemia
10:18

From a 2DE-Gel Spot to Protein Function: Lesson Learned From HS1 in Chronic Lymphocytic Leukemia

Published on: October 19, 2014

13.8K
Modeling Osteosarcoma Using Li-Fraumeni Syndrome Patient-derived Induced Pluripotent Stem Cells
08:52

Modeling Osteosarcoma Using Li-Fraumeni Syndrome Patient-derived Induced Pluripotent Stem Cells

Published on: June 13, 2018

9.0K

Related Experiment Videos

Last Updated: Sep 25, 2025

Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts
07:18

Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts

Published on: June 13, 2019

7.1K
From a 2DE-Gel Spot to Protein Function: Lesson Learned From HS1 in Chronic Lymphocytic Leukemia
10:18

From a 2DE-Gel Spot to Protein Function: Lesson Learned From HS1 in Chronic Lymphocytic Leukemia

Published on: October 19, 2014

13.8K
Modeling Osteosarcoma Using Li-Fraumeni Syndrome Patient-derived Induced Pluripotent Stem Cells
08:52

Modeling Osteosarcoma Using Li-Fraumeni Syndrome Patient-derived Induced Pluripotent Stem Cells

Published on: June 13, 2018

9.0K

Area of Science:

  • Immunology
  • Genetics
  • Infectious Diseases

Background:

  • X-linked lymphoproliferative disease (XLP1) is a severe inborn error of immunity (IEI) caused by SH2D1A mutations, leading to SAP deficiency and immune dysregulation.
  • The SARS-coronavirus (SARS-CoV) typically causes mild disease in children, but severe outcomes are possible.

Observation:

  • A 5-year-old Nepalese boy with agammaglobulinemia and suspected SARS died from diffuse alveolar damage during the SARS outbreak.
  • The patient and his brother were diagnosed with XLP1, a genetic immune disorder.

Findings:

  • This case highlights a fatal SARS-CoV infection in a child with XLP1, contrasting with generally mild pediatric presentations.
  • The study confirms XLP1 in the affected siblings.

Implications:

  • Severe COVID-19 in children necessitates investigation for underlying inborn errors of immunity (IEI).
  • Understanding IEI pathways is crucial for managing severe presentations of infectious diseases like COVID-19 in pediatric populations.