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Updated: Sep 25, 2025
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An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection
Published on: December 10, 2013
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Something Is Changing in Viral Infant Bronchiolitis Approach.
Paolo Bottau1, Lucia Liotti2, Eleonora Laderchi3
1Pediatric and Neonatology Unit, Imola Hospital, Imola, Italy.
Frontiers in Pediatrics
|May 2, 2022
Summary
Bronchiolitis management may need reassessment. A bronchodilator trial is suggested for infants over six months with bronchiolitis, especially those with asthma risk factors.
Area of Science:
- Pediatrics
- Respiratory Medicine
- Clinical Immunology
Background:
- Acute Viral Bronchiolitis is a primary cause of infant hospitalization.
- Current guidelines recommend minimal intervention, often excluding bronchodilators.
- Bronchiolitis may present with diverse phenotypes and endotypes, some linked to later asthma development.
Purpose of the Study:
- To evaluate the potential benefit of bronchodilator therapy in specific bronchiolitis phenotypes.
- To identify patient subgroups who might respond favorably to bronchodilators.
- To inform revised management strategies for acute viral bronchiolitis.
Main Methods:
- Review of current evidence on bronchiolitis phenotypes and treatment responses.
- Analysis of factors, such as age and atopy, influencing disease presentation.
- Consideration of bronchodilator trial protocols for eligible infants.
Main Results:
- Bronchiolitis is not a monolithic disease; distinct phenotypes exist.
- Certain phenotypes are associated with increased risk of developing asthma.
- Infants over six months with bronchiolitis may represent a subgroup benefiting from bronchodilator trials.
Conclusions:
- A personalized therapeutic approach to bronchiolitis is warranted.
- Bronchodilator trials using short-acting β2 agonists are a reasonable consideration for infants > 6 months.
- Further research is needed to precisely link therapeutic options to bronchiolitis phenotypes.
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