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Active Surveillance Program to Increase Awareness on Invasive Fungal Diseases: the French RESSIF Network (2012 to

Stéphane Bretagne1,2, Karine Sitbon1, Marie Desnos-Ollivier1

  • 1Institut Pasteurgrid.428999.7, Université Paris Cité, CNRS, Mycologie Moléculaire, Centre National de Référence Mycoses Invasives et Antifongiques, UMR 2000, Paris, France.

Mbio
|May 2, 2022
PubMed

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Summary

Invasive fungal diseases (IFDs) surveillance in France shows a slight increase in incidence, primarily due to yeast fungemia, and an aging patient population. Despite advances, overall survival rates for IFDs remain unchanged.

Area of Science:

  • Medical Mycology
  • Infectious Diseases Epidemiology
  • Public Health Surveillance

Background:

  • Invasive fungal diseases (IFDs) pose a significant global health challenge, with epidemiology often difficult to ascertain due to diagnostic complexities.
  • Active, nationwide surveillance is crucial for understanding the incidence and trends of IFDs.

Purpose of the Study:

  • To determine the epidemiology of probable and proven invasive fungal diseases (IFDs) in France between 2012 and 2018.
  • To analyze trends in IFD incidence, patient demographics, causative agents, treatment, and outcomes.

Main Methods:

  • Nationwide surveillance program led by the French National Reference Center for Invasive Mycoses and Antifungals.
  • Analysis of 10,886 recorded IFDs between 2012 and 2018, examining incidence, patient age, species distribution, and mortality.
Keywords:
aspergillosiscandidemiaepidemiologyinvasive fungal infectionsmucormycosispneumocytosis

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Main Results:

  • A slight increase in overall IFD incidence (2.16 to 2.36/10,000 hospitalization days), driven by rising yeast fungemia rates.
  • An increasing proportion of patients aged ≥65 years (38.4% to 45.3%).
  • Stable incidence for Pneumocystis pneumonia, invasive aspergillosis, and mucormycosis, but with high mortality rates (42.5% and 59.3% respectively).

Conclusions:

  • IFD epidemiology in France is characterized by an aging patient population and a rise in yeast fungemia incidence.
  • Despite improved diagnostics and treatments, overall survival rates for IFDs have not improved, highlighting the need for further research and intervention strategies.
  • Increased concurrent infections observed, posing diagnostic and therapeutic challenges.