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Updated: Sep 24, 2025

Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway
07:15

Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway

Published on: August 23, 2024

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Interplay between PI3K/AKT pathway and heart disorders

Soudeh Ghafouri-Fard1, Ali Khanbabapour Sasi2, Bashdar Mahmud Hussen3,4

  • 1Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Molecular Biology Reports
|May 2, 2022
PubMed

Insights

The phosphoinositide 3-kinase (PI3K)/AKT pathway regulates cell growth and survival, impacting heart diseases. This review details its role in various cardiac injuries and conditions.

Area of Science:

  • Cardiology
  • Molecular Biology
  • Biochemistry

Background:

  • The phosphoinositide 3-kinase (PI3K)/AKT signaling pathway is vital for cellular functions like growth, proliferation, and survival.
  • This pathway is implicated in the pathogenesis of various cardiovascular disorders.
  • It plays a role in regulating cardiomyocyte size, survival, angiogenesis, and inflammatory responses in the heart.

Purpose of the Study:

  • To review the contribution of the PI3K/AKT pathway in the pathoetiology of cardiac diseases.
  • To explore its role in myocardial injury induced by various toxins and conditions.

Main Methods:

  • Literature review of studies investigating the PI3K/AKT pathway in cardiovascular contexts.
  • Analysis of research on the pathway's involvement in myocardial ischemia/reperfusion injury, myocardial infarction, heart failure, cardiac hypertrophy, cardiomyopathy, and toxin-induced cardiac injury.

Main Results:

  • The PI3K/AKT pathway is a key regulator of cardiomyocyte survival and cardiac function.
  • Dysregulation of this pathway contributes to the development and progression of diverse heart conditions.
  • It is involved in mediating myocardial injury caused by oxidative stress, heavy metals, and cardiotoxic drugs.

Conclusions:

  • The PI3K/AKT pathway is a critical determinant of cardiac health and disease.
  • Targeting this pathway holds therapeutic potential for managing various cardiovascular pathologies.
  • Further research is warranted to fully elucidate its complex roles in cardiac pathoetiology.

Keywords:
Cardiac hypertrophyExpressionHeart diseaseMyocardial infarctionPI3K/AKT pathway

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