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Related Experiment Video

Updated: Sep 24, 2025

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Cell-based carrier for targeted hitchhiking delivery.

Tonggong Liu1,2, Cheng Gao2,3, Dayong Gu4

  • 1Department of Preventive Medicine, School of Public Health, Dongguan Key Laboratory of Environmental Medicine, Guangdong Medical University, Dongguan, 523808, China.

Drug Delivery and Translational Research
|May 2, 2022
PubMed
Summary

Cell-based drug delivery systems utilize cells as carriers for enhanced biocompatibility and targeting efficiency. Understanding different construction strategies is crucial for optimizing therapeutic outcomes and clinical translation.

Keywords:
Cell-based carrierClinical translationConstructDrug delivery system

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Pharmacology

Background:

  • Conventional drug delivery systems face limitations in transport efficiency and therapeutic efficacy.
  • Cell-based drug delivery systems are emerging as a promising alternative, leveraging cells as natural carriers.
  • These systems offer improved biocompatibility and targeting due to inherent cellular functions.

Purpose of the Study:

  • To summarize recent advancements in cell-based drug delivery systems.
  • To discuss various strategies for constructing cell-based drug carriers.
  • To analyze the applications, advantages, disadvantages, and clinical translation challenges of these systems.

Main Methods:

  • Review of recent scientific literature on cell-based drug delivery systems.
  • Categorization of different cell-based carrier types and their preparation methodologies.
  • Analysis of therapeutic applications and clinical translation hurdles.

Main Results:

  • Cell-based carriers demonstrate significant advantages over conventional systems, including enhanced biocompatibility and targeting.
  • Various construction strategies exist, such as direct drug internalization or surface conjugation.
  • Different cell types and preparation methods impact carrier function and clinical applicability.

Conclusions:

  • A comprehensive understanding of cell-based carrier construction is vital for maximizing therapeutic benefits.
  • Addressing challenges in clinical translation is key to realizing the full potential of cell-based drug delivery.
  • Further technological development is needed to accelerate the clinical application of these advanced systems.