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Spiropyrimidinetrione DNA Gyrase Inhibitors with Potent and Selective Antituberculosis Activity

Preshendren Govender1, Rudolf Müller1, Kawaljit Singh1

  • 1Drug Discovery and Development Centre (H3D), Department of Chemistry, University of Cape Town, Rondebosch, Cape Town 7701, South Africa.

Journal of Medicinal Chemistry
|May 2, 2022
PubMed
Summary

New spiropyrimidinetriones (SPTs) show potent activity against drug-resistant tuberculosis (TB) by inhibiting Mycobacterium tuberculosis DNA gyrase. These novel compounds offer a promising new avenue for TB treatment, demonstrating selective efficacy and a unique mechanism of action.

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