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Updated: Sep 24, 2025
Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451
Published on: April 18, 2025
CURVED MULTIFORMAT IMAGING OF STRUCTURAL MRI AS A BIOMARKER FOR PROFILING OF VARIOUS DEMENTIA - AN ALGORITHMIC
Sandhya Mangalore1, Sameer Peer1, Arun Kumar Gupta1
1Department of Neuroimaging and Interventional Radiology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka 560029, India.
Background:
Dementia is one of the most common clinical entities for which neuroimaging is done for diagnosis and characterization of the sub-types.
Objective:
Advanced neuroimaging modalities like MR-PET have added to the armamentarium of the neuroradiologists for the diagnosis of specific types of dementia syndromes. However, advanced molecular imaging is expensive and is not widely available particularly in underdeveloped countries. Structural imaging with MRI in addition to the clinical work up remains the most useful approach to the diagnosis of dementia in our setup.
Material And Methods:
We describe a simple technique of curved multiplanar reconstruction of brain images with the use of a simple reconstruction software which can help in recognition of pattern of atrophy in dementias and thus improve the diagnostic accuracy of structural MRI.
Results:
Using this approach of pattern recognition, we suggest a simplified algorithm for diagnosis of sub-types of dementia.
Conclusions:
In our study, we applied this technique for demonstration of pattern of atrophy which correlated with metabolic changes on PET in a variety of dementia cases using simultaneous MR-PET imaging and may act as a low cost and reliable biomarker to profile dementia subtypes. To the best of our knowledge this is the first study to show the utility of curved multiplanar reconstruction in dementias.
