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caliPER: A software for blood-free parametric Patlak mapping using PET/MRI input function.

Praveen Dassanayake1, Lumeng Cui2, Elizabeth Finger3

  • 1Lawson Health Research Institute, London, Ontario, Canada; Department of Medical Biophysics, Western University, London, Ontario, Canada.

Neuroimage
|May 2, 2022
PubMed
Summary
This summary is machine-generated.

This study introduces caliPER software for absolute Positron Emission Tomography (PET) quantification without arterial blood sampling. It simplifies pharmacokinetic analysis using PET/MRI image-derived input functions, enabling easier clinical application.

Keywords:
Image-derived input functionPET/MRIParametric imagingPatlak graphical analysis

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Area of Science:

  • Nuclear Medicine
  • Medical Imaging
  • Pharmacokinetics

Background:

  • Absolute quantification in PET imaging is hindered by the need for arterial blood sampling and complex pharmacokinetic analysis.
  • PET/MRI offers a potential solution for blood-free quantification using image-derived input functions (IDIFs).

Purpose of the Study:

  • To introduce caliPER, a software tool for simplified pharmacokinetic modeling of PET probes using PET/MR IDIFs and Patlak Plot analysis.
  • To evaluate caliPER's performance for blood-free quantification of irreversible PET tracers.

Main Methods:

  • Developed caliPER software for pharmacokinetic modeling using PET/MR IDIFs and Patlak analysis.
  • Utilized reconstructed dynamic PET images and aligned anatomical MRI for IDIF vessel delineation.
  • Evaluated caliPER using [18F]FDG in region-based and pixel-wise analyses, comparing IDIFs to arterial blood input functions.

Main Results:

  • caliPER-derived IDIFs, corrected for partial volume errors, showed minimal bias (6-8%) compared to arterial blood input functions, even in small vessels.
  • Kinetic parameters (Ki) and glucose metabolism estimates using caliPER were highly consistent with those from arterial blood sampling (<2% difference).
  • Demonstrated successful application in imaging brain glucose hypometabolism in Frontotemporal Dementia.

Conclusions:

  • caliPER provides a promising, simplified approach for absolute PET tracer quantification in clinical settings.
  • The software eliminates the need for arterial blood sampling, making advanced pharmacokinetic analysis more accessible.
  • caliPER facilitates parametric imaging and analysis for irreversible PET tracers without invasive procedures.