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Related Experiment Video

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Author Spotlight: Advancing Allergic Rhinitis Research with Multicolor Immunofluorescence
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Does allergen immunotherapy for allergic rhinitis prevent asthma?

Syed Hasan Arshad1

  • 1Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom; The David Hide Asthma and Allergy Research Centre, Isle of Wight, United Kingdom; Biomedical Research Centre, University Hospital Southampton, Southampton, United Kingdom.

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
|May 2, 2022
PubMed
Summary

Allergen immunotherapy (AIT) can prevent asthma development in children with allergic rhinitis (AR). Evidence supports AIT for pollen allergies, but more research is needed for house dust mite allergies.

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Area of Science:

  • Immunology
  • Allergology
  • Pediatrics

Background:

  • Asthma and allergic rhinitis share T helper 2-driven inflammation.
  • Children with allergies are at risk of developing asthma.
  • Allergen immunotherapy (AIT) treats existing allergies and may prevent new ones.

Purpose of the Study:

  • To evaluate the effectiveness of AIT in preventing asthma in children with allergic rhinitis.
  • To assess the potential of AIT to alter the natural course of allergic disease.

Main Methods:

  • Review of observational studies and clinical trials on AIT for seasonal and perennial allergic rhinitis.
  • Analysis of evidence for AIT's asthma-preventive effects in different allergic conditions.

Main Results:

  • Evidence suggests AIT for grass and birch pollen allergies can prevent asthma in children with allergic rhinitis.
  • Results for AIT in house dust mite-induced allergic rhinitis are less convincing.
  • Existing studies often have small sample sizes or methodological limitations.

Conclusions:

  • AIT shows promise in preventing asthma progression in children with allergic rhinitis, particularly for pollen allergies.
  • Further well-designed, adequately powered studies are necessary to confirm these findings and assess cost-effectiveness.