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Updated: Sep 24, 2025
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Author Spotlight: A Non-Intubated Video-Assisted Thoracoscopic Surgery with Multimodal Analgesia and Sevoflurane Inhalation Anesthesia
Published on: May 26, 2023
1.8K
Video-assisted thoracoscopic surgery for primary pulmonary cryptococcosis
Chao-Wen Lu1, Wang-Da Liu2, Hsao-Hsun Hsu1
1Division of Thoracic Surgery, Department of Surgery, National Taiwan University Hospital, and National Taiwan University College of Medicine, Taiwan.
Summary
Video-assisted thoracoscopic surgery (VATS) is effective for primary pulmonary cryptococcosis. This study shows VATS is a safe diagnostic and therapeutic tool, with a low serum cryptococcal antigen (CryAg) detection rate.
Area of Science:
- Pulmonology
- Infectious Diseases
- Thoracic Surgery
Background:
- The surgical outcomes for primary pulmonary cryptococcosis are not well-defined.
- This study examines the characteristics, treatment, and outcomes of video-assisted thoracoscopic surgery (VATS) for primary pulmonary cryptococcosis.
Purpose of the Study:
- To investigate the clinical characteristics, treatment, and outcomes of VATS for primary pulmonary cryptococcosis.
- To compare serum cryptococcal antigen (CryAg)-positive and CryAg-negative patients undergoing VATS.
Main Methods:
- Retrospective review of 49 patients with pulmonary cryptococcosis who underwent VATS for pulmonary nodules.
- Comparison of clinical data between serum CryAg-positive and CryAg-negative patient groups.
Main Results:
- Most patients were asymptomatic (67.3%), diagnosed via CT scans.
- A higher proportion of CryAg-positive patients underwent lobectomy (62.5%) versus CryAg-negative patients (7.3%).
- No relapse occurred in 48 patients post-VATS, regardless of antifungal treatment.
Conclusions:
- Serum CryAg detection rate is low in primary pulmonary cryptococcosis.
- VATS is an effective and safe diagnostic and therapeutic approach for this condition.
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