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Updated: Sep 24, 2025

Chemo-enzymatic Synthesis of N-glycans for Array Development and HIV Antibody Profiling
Published on: February 5, 2018
Shared sugars - parasite glycan homology in HIV-1 vaccine design
Lachlan P Deimel1, Quentin J Sattentau1
1The Sir William Dunn School of Pathology, University of Oxford, Oxford, OX1 3RE, UK.
Abstract:
Immune tolerance to self-glycans is a host mechanism to avoid autoimmunity, which is exploited by HIV-1 coating its envelope glycoproteins with glycans to evade neutralising antibodies (nAbs). Huettner et al. describe cross-reactivity between Schistosoma mansoni glycans and HIV-1 envelope glycoprotein glycans, suggesting a strategy for induction of HIV-1 nAbs by vaccination.
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