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Utilizing chemokines in cancer immunotherapy.
Florian Märkl1, Duc Huynh2, Stefan Endres3
1Center for Integrated Protein Science Munich (CIPS-M) and Division of Clinical Pharmacology, Department of Medicine IV, Klinikum der Universität München, LMU, Munich, Germany; Member of the German Center for Lung Research (DZL), Munich, Germany.
Trends in Cancer
|May 2, 2022
Summary
Chemokines, crucial for immune cell movement, can predict patient responses to cancer immunotherapy and offer new strategies to improve treatment effectiveness against various cancers.
Area of Science:
- Oncology
- Immunology
- Cancer Biology
Background:
- Immune checkpoint inhibitors and chimeric antigen receptor (CAR) T cell therapies show promise in cancer treatment.
- However, limited patient response and relapse highlight the need for enhanced immunotherapy strategies.
Purpose of the Study:
- To review the role of chemokines in the tumor microenvironment (TME).
- To discuss strategies for using chemokines or chemokine antagonism to improve cancer immunotherapy.
Main Methods:
- Literature review of preclinical and clinical studies.
- Analysis of chemokine functions in TME and their impact on immune cell trafficking.
Main Results:
- Chemokines influence TME composition and immune cell infiltration.
- Chemokines can act as prognostic biomarkers for immunotherapy response.
- Targeting chemokines offers potential therapeutic strategies.
Conclusions:
- Chemokines are key regulators of the immune response within the TME.
- Utilizing chemokines or chemokine antagonism presents a promising avenue for improving immunotherapy efficacy.
- Further research into chemokine-based strategies could overcome resistance and enhance patient outcomes in cancer treatment.
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