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Compound polyglactin 910/polypropylene small vessel prostheses.

H P Greisler, D U Kim, J W Dennis

    Journal of Vascular Surgery
    |April 1, 1987
    PubMed
    Summary
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    This study shows that polyglactin 910 (PG910) and polypropylene vascular prostheses exhibit excellent patency and mechanical strength in rabbits. The prostheses develop a stable, endothelial-like lining and demonstrate favorable biochemical profiles over time.

    Area of Science:

    • Biomaterials Science
    • Vascular Surgery
    • Tissue Engineering

    Background:

    • Vascular prostheses are crucial for replacing damaged or diseased vessels.
    • Developing prostheses that integrate well with host tissue and maintain long-term function is a key challenge.

    Purpose of the Study:

    • To evaluate the tissue response, mechanical properties, and biochemical characteristics of a novel polyglactin 910 (PG910) and polypropylene composite vascular prosthesis in a rabbit model.

    Main Methods:

    • Implantation of 42 PG910/polypropylene prostheses into rabbit aortas.
    • Explantation and analysis at intervals from 2 weeks to 12 months.
    • Morphological assessment (microscopy), mechanical testing (compliance, bursting strength), and biochemical assays (prostacyclin, thromboxane production).

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    Main Results:

    • 100% patency with minimal stenosis (2%) and no aneurysms observed.
    • Prostheses were covered by confluent endothelial-like cells and smooth muscle-like myofibroblasts within 1-2 months, with polypropylene degradation.
    • Regenerated tissues exhibited superior bursting strength compared to native aorta and favorable prostacyclin/thromboxane production ratios.

    Conclusions:

    • The PG910/polypropylene composite demonstrates clinically effective morphologic, mechanical, and biochemical characteristics for vascular repair.
    • This composite material elicits a favorable tissue response, promoting regeneration and long-term patency.