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Ultrathin metal-organic framework nanosheets offer enhanced properties like light transmittance and electrical conductivity. This review explores their fabrication, bioapplications in biocatalysis, biosensors, and nanomedicine for cancer therapy.

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Chemistry

Background:

  • Metal-organic frameworks (MOFs) are crystalline porous materials with tunable properties.
  • Ultrathin two-dimensional MOF nanosheets exhibit enhanced characteristics due to their planar structure.
  • These properties are crucial for advanced technological and biomedical applications.

Purpose of the Study:

  • To review the unique structural properties of ultrathin MOF nanosheets.
  • To summarize design strategies and fabrication methods for MOF nanosheets.
  • To present current bioapplications and future prospects of 2D MOFs.

Main Methods:

  • Literature review focusing on ultrathin MOF nanosheets.
  • Analysis of structural properties like light transmittance and electrical conductivity.
  • Compilation of fabrication techniques and bioapplication data.

Main Results:

  • Ultrathin MOF nanosheets possess superior light transmittance and electrical conductivity.
  • Various fabrication methods enhance the accessibility and applicability of MOF nanosheets.
  • Significant progress in bioapplications including biocatalysis, biosensors, and theranostics.

Conclusions:

  • Ultrathin MOF nanosheets show great promise for diverse technological applications.
  • Reactive oxygen species-based nanomedicine derived from 2D MOFs is a key area for oncology.
  • Further research is needed to overcome challenges and explore new frontiers for 2D MOFs.