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Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
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Nanozyme-natural enzymes cascade catalyze cholesterol consumption and reverse cancer multidrug resistance

Bin Du1,2, Mei Zheng1, Huizhen Ma1

  • 1School of Pharmaceutical Sciences, Zhengzhou University, 100 Science Road, Zhengzhou, 450001, People's Republic of China.

Journal of Nanobiotechnology
|May 3, 2022
PubMed

Insights

This study introduces a novel nanosystem that uses cholesterol breakdown to generate cancer-killing hydroxyl radicals. This system targets tumor cells, effectively reversing multidrug resistance and improving cancer treatment outcomes.

Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Cancer Research

Background:

  • Multidrug resistance (MDR) remains a significant challenge in cancer therapy.
  • Conventional strategies targeting P-glycoprotein (P-gp) show limited efficacy in overcoming MDR.

Purpose of the Study:

  • To develop a novel nanosystem for reversing multidrug resistance in cancer.
  • To leverage cascade catalytic reactions and targeted drug delivery for enhanced therapeutic effects.

Main Methods:

  • Immobilization of Cholesterol Oxidase (COD) onto NH2-MIL-88B (MOF) carrier.
  • Utilizing MOF's peroxidase-like activity to generate hydroxyl radicals (•OH) from H2O2.
  • Encapsulating doxorubicin (DOX) within the MOF and coating with chondroitin sulfate (CS) for CD44 targeting.

Main Results:

  • The nanosystem effectively consumes cholesterol, producing reactive oxygen species (ROS) for cancer cell killing.
  • CD44-targeted CS-shell facilitates precise drug delivery to tumor sites.
  • Demonstrated potential in reversing multidrug resistance by overcoming P-gp efflux.

Conclusions:

  • The developed nanosystem offers a promising strategy for overcoming cancer multidrug resistance.
  • Cascade catalytic consumption of cholesterol and targeted delivery enhance therapeutic efficacy.
  • This approach provides a new avenue for developing advanced cancer treatments.
Keywords:
ApoptosisCholesterolCholesterol oxidaseChondroitin sulfateFluidityLipid raftReverse drug resistance

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