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Update on diagnosis and management of refractory corneal infections

Shweta Agarwal1, Tanveer A Khan2, Murugesan Vanathi2

  • 1Dr. G. Sitalakshmi Memorial Clinic for Ocular Surface Disorders, C. J. Shah Cornea Services, Medical Research Foundation, Sankara Nethralaya, Chennai, Tamil Nadu, India.

Indian Journal of Ophthalmology
|May 3, 2022
PubMed

Insights

Refractory infectious keratitis, often caused by antimicrobial resistance, requires a comprehensive approach. Understanding ocular and systemic factors, biofilm formation, and new therapies is crucial for effective management and preventing vision loss.

Area of Science:

  • Ophthalmology
  • Microbiology
  • Infectious Diseases

Background:

  • Infectious keratitis poses a significant threat to vision, complicated by rising antimicrobial resistance.
  • Refractory cases result from factors like ocular surface disease, diagnostic delays, virulent organisms, and immunosuppression.

Purpose of the Study:

  • To review current literature on the diagnosis and treatment of refractory infectious keratitis.
  • To explore emerging strategies and future directions for managing challenging corneal ulcers.

Main Methods:

  • Comprehensive literature review of studies on refractory keratitis.
  • Analysis of factors contributing to treatment resistance and biofilm formation.
  • Evaluation of novel therapeutic approaches and drug delivery systems.

Main Results:

  • Understanding of ocular/systemic factors and biofilm formation is key to managing refractory keratitis.
  • Improved drug bioavailability and alternative therapies offer new treatment avenues.
  • A multidimensional diagnostic and management strategy is essential.

Conclusions:

  • Effective management of refractory keratitis necessitates a multifaceted approach.
  • Continued research into novel therapies and diagnostic methods is vital.
  • Preventing corneal perforation and disease spread requires timely and appropriate intervention.
Keywords:
Adjunctive therapycorneal ulcersrefractory infectious keratitis

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