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Proprotein convertase subtilisin/kexin type 9 is associated with atherosclerosis in patients with Behcet's disease

Rabia Aydogan Baykara1, Pinar Diydem Yilmaz2, Mevlüt Hakan Göktepe3

  • 1Department of Physical Medicine and Rehabilitation, Malatya Turgut Ozal University, Malatya, Turkey.

Clinical and Experimental Hypertension (New York, N.Y. : 1993)
|May 3, 2022
PubMed

Insights

Proprotein convertase subtilisin/kexin type 9 (PCSK9) is independently associated with subclinical atherosclerosis in Behcet

Area of Science:

  • Cardiovascular Medicine
  • Rheumatology
  • Biochemistry

Background:

  • Behcet's disease (BD) is linked to increased cardiovascular disease risk.
  • Proprotein convertase subtilisin/kexin type 9 (PCSK9) accelerates atherosclerosis.
  • Subclinical atherosclerosis markers like carotid artery intima-media thickness (cIMT) are crucial in BD patients.

Purpose of the Study:

  • To investigate the relationship between PCSK9 levels and cIMT in BD patients.
  • To determine if PCSK9 is associated with BD disease activity.
  • To explore PCSK9 as a potential biomarker for atherosclerosis in BD.

Main Methods:

  • A case-control study involving 58 BD patients and 58 healthy controls.
  • Measurement of carotid artery intima-media thickness (cIMT).
  • Quantification of serum PCSK9 levels and assessment of BD disease activity.

Main Results:

  • BD patients exhibited significantly higher cIMT and PCSK9 levels compared to controls.
  • A significant independent association was found between PCSK9 and cIMT (p < 0.050).
  • No independent association was observed between PCSK9 and BD disease activity.

Conclusions:

  • PCSK9 is strongly and independently associated with subclinical atherosclerosis in Behcet's disease.
  • PCSK9 may serve as a marker for atherosclerosis in BD patients.
  • The association between PCSK9 and BD disease activity appears limited.
Abstract

Keywords:
Behcet’sProprotein convertase subtilisin/kexin type 9 (PCSK9)atherosclerosiscarotid artery intima-media thickness (cIMT)

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