N⁶-methyladenosine (m⁶A) reader IGF2BP2 promotes gastric cancer progression via targeting SIRT1

N⁶-methyladenosine (m⁶A) modification acts as the most prevalent internal modification in eukaryotic mRNA. Emerging evidence shows the critical biological roles of m⁶A key enzymes in human cancers. However, the roles of m⁶A binding protein IGF2BP2 in gastric cancer (GC) progression are still unclear. In this study, we confirmed that IGF2BP2 was highly expressed in GC cell lines and tumor tissues. Knocking down of IGF2BP2 suppressed cell proliferation and migration, and repressed xenograft tumor growth in vivo, while IGF2BP2 overexpression promoted the proliferation and migration. Mechanistically, we identified that IGF2BP2 regulated GC the proliferation/migration through recognizing the m⁶A modification sites of SIRT1 mRNA. In general, our findings demonstrated a novel regulatory mechanism that IGF2BP2/SIRT1 axis modulated GC progression in an m⁶A-dependent manner, suggesting that m⁶A may be a therapeutic target for GC.