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A new look at the haemopoietic response to cytotoxic agents and stem cell regulation
Leukemia Research
|January 1, 1987
Abstract:
A re-evaluation of the response of haemopoietic stem cells, in mice, to radiation and anticancer drugs suggests a precise mechanism for the regulation of the number of stem cells through a control of their rate of differentiation. This analysis which has some counter-intuitive aspects, appears to be the first attempt to obtain a unified explanation for various effects of cytotoxic agents and has some important biological and clinical implications.