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Related Concept Videos

Negative and Cognitive Symptoms of Schizophrenia01:30

Negative and Cognitive Symptoms of Schizophrenia

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Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
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Schizophrenia01:17

Schizophrenia

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Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those...
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Positive Symptoms of Schizophrenia: Hallucinations and Delusions01:30

Positive Symptoms of Schizophrenia: Hallucinations and Delusions

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Schizophrenia is a complex mental health disorder that can manifest with various positive symptoms, including thought, movement, and behavior disorders. These symptoms significantly disrupt cognitive and motor functions, leading to profound effects on an individual's ability to engage with the world.
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Disorganized and unusual thought processes mark thought disorders in schizophrenia. One key feature is disorganized speech, where an individual's conversation includes...
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Depressive Disorders: MDD and Dysthymia01:27

Depressive Disorders: MDD and Dysthymia

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Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
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Positive Symptoms Schizophrenia: Hallucinations and Delusions01:26

Positive Symptoms Schizophrenia: Hallucinations and Delusions

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Schizophrenia is a complex psychiatric disorder characterized by a range of symptoms that significantly impact cognition, behavior, and emotional regulation. Among these, the positive symptoms stand out as they involve the addition or exaggeration of normal mental functions, deviating markedly from typical behavior and perception. Hallucinations and delusions are prominent positive symptoms, each profoundly affecting the individual's experience of reality.
Hallucinations
Hallucinations in...
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Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

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Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
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Updated: Sep 24, 2025

The Unpredictable Chronic Mild Stress Protocol for Inducing Anhedonia in Mice
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Anhedonia in Schizophrenia.

Erin K Moran1, Adam J Culbreth2, Deanna M Barch3,4,5

  • 1Department of Psychological and Brain Sciences, Washington University in St. Louis, St. Louis, MO, USA.

Current Topics in Behavioral Neurosciences
|May 3, 2022
PubMed
Summary
This summary is machine-generated.

Anhedonia in schizophrenia involves more than just reduced pleasure. Research shows impaired reward anticipation, learning, and decision-making, impacting functional outcomes and treatment.

Keywords:
AnhedoniaMotivationRewardSchizophrenia

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Affective Science

Background:

  • Anhedonia is a core symptom of schizophrenia, linked to poor functional outcomes.
  • Recent research suggests individuals with schizophrenia can experience pleasure, but affective dynamics and decision-making are impaired.

Purpose of the Study:

  • To explore emotional and motivational impairments in schizophrenia beyond simple pleasure deficits.
  • To examine mechanisms including reward response, anticipation, learning, effort-based decision-making, and cognitive control.

Main Methods:

  • Review of studies using diverse rewards (monetary, social) to assess anhedonia mechanisms.
  • Analysis of temporal affective dynamics and decision-making processes in schizophrenia.

Main Results:

  • Schizophrenia impairs reward anticipation, learning, and effort-cost decision-making.
  • Working memory and cognitive control also play roles in motivational deficits.

Conclusions:

  • Anhedonia in schizophrenia is multifaceted, involving complex affective and cognitive processes.
  • Modern assessment should integrate these mechanisms for a nuanced understanding and improved treatment strategies.