The Good Compliance is an Opportunity to Avoid Pathological Brain Aging

Preservation of health, increase in life expectancy determine the need to improve the effectiveness of medical recommendations, which, despite the success of pharmacology, are insufficient for reasons related to the low level of compliance with these recommendations by patients. The authors of the article believe that compliance is a kind of quantifiable and behaviorally realized reflection of therapeutic interaction, refracted through the prism of the patient's individual personality characteristics. Participants of the study-148 employees of medical institutions: 12 men, 136 women, their age ranged from 27 to 74 years. The research tool was the neuropsychological rapid method. 3 research subgroups were formed: 27-40 years (37 people), 41-50 years (60 people), 51 years and older (51 people). Comparison of the results of subtests of neuropsychological Express technique showed heterogeneous results in subgroups of the study. In addition, the dynamic characteristics of psychological processes were evaluated: depletion, inertia, impulsivity. A significant difference in the performance of the graphomotor test between the subjects of the age subgroup of 27-40 years and the subgroup of 41-50 years was statistically confirmed. For the qualitative performance of this simple test requires a sufficient level of development of all structural and functional components of brain functions and, in particular, the "front" function of programming and management and consistent organization of movements. In older people revealed a much greater number of errors, interruptions of the test than the representatives of the more "young" subgroup. Similar results were obtained when comparing the "young" and "old" subgroups. Despite the absence of signs of decompensation of concomitant pathology, representatives of the subgroups took a different amount of concomitant therapy. Using the scale of assessment of drug compliance, it was found that compliance is most reduced in the subgroup of 41-50 years. In this subgroup, a comprehensive decrease in compliance across the "behavioral", "emotional", and "cognitive" domains was detected in 87.8% of cases, while in the younger subgroup partial non-compliance was 32.4%, in the older subgroup - 74.5% An analysis of the states of cognitive functions in 52 representatives of the middle age subgroup with low compliance rates showed that, unlike other representatives of the same subgroup, their indices for a number of neuropsychological tests are close to the results of more adult participants in the study. Individuals demonstrating low compliance with quite favorable CNS resources are at risk for the formation of pathological aging.