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Related Concept Videos

Tissue Transplantation01:24

Tissue Transplantation

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Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
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Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

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A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

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Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
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Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

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Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
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Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

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Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
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Immunodeficiency Diseases01:25

Immunodeficiency Diseases

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Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
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Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation
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Ascorbic acid in solid organ transplantation: A literature review.

Francesca Gori1, Jacopo Fumagalli1, Caterina Lonati2

  • 1Department of Anesthesia, Critical Care and Emergency, Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, Milan, Italy.

Clinical Nutrition (Edinburgh, Scotland)
|May 3, 2022
PubMed
Summary

Ascorbic Acid (AA) shows promise in mitigating ischemia/reperfusion (I/R) injury during organ transplantation. Further research is needed to clarify optimal use for reducing graft dysfunction and rejection.

Keywords:
Antioxidant therapyAscorbic acidIschemia/reperfusion injuryOxidative stressTransplantationVitamin C

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A Rapid and Specific Microplate Assay for the Determination of Intra- and Extracellular Ascorbate in Cultured Cells
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Area of Science:

  • Biochemistry
  • Immunology
  • Transplantation Medicine

Background:

  • Ischemia/reperfusion (I/R) injury is a major cause of graft dysfunction and rejection post-transplantation.
  • Excessive free radicals and depleted antioxidants contribute to I/R injury and organ damage.
  • Ascorbic Acid (AA) possesses antioxidant, anti-apoptotic, and anti-inflammatory properties.

Purpose of the Study:

  • To review Ascorbic Acid's (AA) role in mitigating ischemia/reperfusion (I/R) injury in solid organ transplantation.
  • To explore AA's metabolic pathways and therapeutic potential.
  • To address the controversy surrounding AA's effectiveness, optimal dosage, timing, and combinations.

Main Methods:

  • Literature review of preclinical and clinical studies on Ascorbic Acid in transplantation.
  • Analysis of AA-modulated metabolic pathways relevant to I/R injury.
  • Synthesis of evidence regarding AA's impact on graft outcomes.

Main Results:

  • Ascorbic Acid (AA) demonstrates potential in reducing I/R injury due to its antioxidant and anti-inflammatory effects.
  • Evidence suggests AA may modulate apoptosis and improve graft viability.
  • Optimal therapeutic strategies for AA in transplantation remain under investigation.

Conclusions:

  • Ascorbic Acid (AA) is a safe, cost-effective micronutrient with potential benefits for solid organ transplantation.
  • Further research is required to establish definitive protocols for AA administration.
  • Clarifying AA's role could improve outcomes for kidney, liver, lung, heart, and pancreas transplants.