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Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA

Published on: February 9, 2011

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Inpatient outcomes for children receiving empiric methicillin-resistant Staphylococcus aureus coverage for

Jessica L Markham1,2, Sophia Hackman3, Matt Hall1,4

  • 1Department of Pediatrics, Children's Mercy Kansas City, University of Missouri-Kansas City School of Medicine, Kansas City, Missouri, USA.

Journal of Hospital Medicine
|May 3, 2022
PubMed

Insights

Antibiotic management for pediatric complicated pneumonia lacks evidence. Most children received MRSA coverage, but outcomes like hospital stay and readmissions were similar with or without it.

Area of Science:

  • Pediatric Infectious Diseases
  • Antimicrobial Stewardship
  • Clinical Outcomes Research

Background:

  • Evidence for optimal antibiotic management in pediatric complicated pneumonia is limited.
  • This variability contributes to diverse empiric antibiotic choices.
  • Methicillin-resistant Staphylococcus aureus (MRSA) is a concern in pediatric pneumonia.

Purpose of the Study:

  • To describe the use of empiric antibiotics with and without MRSA coverage in hospitalized children with complicated pneumonia.
  • To evaluate the association between MRSA coverage and clinical outcomes.

Main Methods:

  • Retrospective analysis of the Pediatric Health Information System database.
  • Inclusion of children hospitalized with complicated pneumonia.
  • Grouping patients based on empiric antibiotic selection (with or without MRSA coverage) on Day 0-1.
  • Utilizing generalized linear mixed effects models for outcome analysis.

Main Results:

  • Over 70% of hospitalized children received empiric antibiotics with MRSA coverage.
  • No significant differences were observed in length of stay between groups.
  • Rates of repeat pleural drainage, 7-day ED revisits, and 7-day readmissions were similar regardless of MRSA coverage.

Conclusions:

  • Current empiric antibiotic strategies for pediatric complicated pneumonia often include MRSA coverage.
  • Clinical outcomes did not significantly differ based on the use of MRSA-targeted antibiotics.
  • Further prospective research is needed to inform national guidelines on MRSA coverage for pediatric pneumonia.

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