Noise exposure and risk of myocardial infarction incidence and mortality: a dose-response meta-analysis

The strength and shape of the dose-response relationship between different types of noise and myocardial infarction (MI) remain unclear. Therefore, we aimed to summarize the evidence of the association between various types of noise and MI incidence and mortality through a dose-response meta-analysis. We performed a systematic search of the PubMed, Embase, and Web of Science databases up to December 19, 2021. The generalized least-squares method and restricted cubic splines were used to assess the potential linear and nonlinear dose-response relationships between noise exposure and the risk of MI events. Twenty observational studies with 34 reports met the eligibility criteria. In the linear models, the pooled relative risk and corresponding 95% confidence interval (CI) for MI incidence was 1.04 (95% CI: 1.02 - 1.05), and the MI mortality was 1.02 (95% CI: 1.02 - 1.03) for each 10 dB(A) increase in noise exposure. In addition, we observed an approximately J-shaped dose-response relationship between noise and MI mortality (P_nonlinearity = 0.0037), whereas the threshold for the statistical impact of noise on MI mortality may be 42 dB(A). Our findings support the notion that various types of noise exposure have a positive dose-response relationship with the risk of MI incidence and mortality.