Combination of Photodynamic Therapy and Therapeutic Vaccination
Jan Willem Kleinovink1, Ferry Ossendorp2
1Department of Immunology, Tumor Immunology Group, Leiden University Medical Center, Leiden, The Netherlands.
Abstract:
Tumor ablation by photodynamic therapy (PDT) results in a strong reduction in tumor mass and can lead to improved recognition of tumor cells by the immune system. This supports combinations of PDT and immunotherapy for the treatment of advanced tumors. Therapeutic vaccination is a tumor-specific type of cancer immunotherapy that aims to directly strengthen the immune response against tumor antigens. In this chapter, we describe the combination of PDT and therapeutic vaccination using a peptide tumor antigen vaccine.
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