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Abnormal glucose regulation in Chinese patients with coronary artery disease: a gender analysis

Juan Liu1, Li-Qun He1, Wei Zhu1

  • 1Department of Cardiology of Wuhan, No.1 Hospital, No. 215 Zhongshan Avenue, Wuhan, 430022, Hubei Province, China.

Journal of Cardiothoracic Surgery
|May 3, 2022
PubMed

Insights

Abnormal glucose regulation is common in patients with coronary artery disease (CAD). This study found that women with CAD have a higher prevalence of diabetes mellitus and impaired glucose regulation compared to men.

Area of Science:

  • Cardiology
  • Endocrinology
  • Public Health

Background:

  • Diabetes and impaired glucose regulation are highly prevalent in patients with coronary artery disease (CAD).
  • Understanding the prevalence of these conditions in different demographics is crucial for patient care.

Purpose of the Study:

  • To investigate the prevalence of abnormal glucose regulation in Chinese patients with coronary artery disease.
  • To compare the prevalence of diabetes and impaired glucose regulation between men and women with CAD.

Main Methods:

  • A retrospective study of 4100 patients with CAD (2873 males, 1227 females) aged 63 years on average.
  • Collected and analyzed demographic data, medical history, echocardiography findings, and blood investigations.
  • Utilized oral glucose tolerance tests (OGTT) for patients not diagnosed with diabetes.

Main Results:

  • 24% of patients had type 2 diabetes mellitus, with a higher prevalence in females (27%) than males (23%).
  • Among patients without diagnosed diabetes, 48% underwent OGTT, revealing higher rates of type 2 diabetes and impaired glucose regulation (IGR) in women.
  • Abnormal glucose regulation was more prevalent in females (p < 0.01), with women being more prone to diabetes mellitus or IGT (OR 1.44 and 1.43, respectively).

Conclusions:

  • Abnormal glucose regulation is highly prevalent in patients with coronary artery disease.
  • Women with CAD are significantly more prone to developing diabetes mellitus or impaired glucose regulation than men.
Abstract

Keywords:
Coronary artery diseaseDiabetesIGTOGTTWomen

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