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pH-Responsive Self-Assembling Peptide-Based Biomaterials: Designs and Applications.

Zhao Li¹, Yumeng Zhu¹, John B Matson¹

¹Department of Chemistry, Virginia Tech Center for Drug Discovery, and Macromolecules Innovation Institute, Virginia Tech, Blacksburg, Virginia 24061, United States.

ACS Applied Bio Materials

|May 3, 2022

Summary

This summary is machine-generated.

pH-responsive peptide biomaterials offer tunable platforms for targeted drug delivery and tissue engineering. These self-assembling nanomaterials leverage environmental pH changes for controlled release and matrix mimicry.

Keywords:

cancer therapy cell-adhesive peptides cell-penetrating peptides pH-responsive tissue regeneration tumor-targeting wound-healing

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Area of Science:

Biomaterials Science
Nanotechnology
Biochemistry

Background:

Stimuli-responsive peptide-based biomaterials are gaining traction for targeted therapies.
Endogenous pH changes in abnormal microenvironments make pH a particularly useful stimulus.
Peptides incorporating pH-responsive elements self-assemble into nanostructures.

Purpose of the Study:

To review design motifs and mechanisms of pH-responsiveness in self-assembling peptide biomaterials.
To highlight recent advances in drug delivery and tissue engineering applications.
To identify future challenges and development areas.

Main Methods:

Review of existing literature on pH-responsive peptide biomaterials.
Analysis of design strategies for pH-responsiveness.
Focus on self-assembly into nanostructures.
Examination of applications in drug delivery and tissue engineering.

Main Results:

pH-responsive peptides self-assemble into various nanostructures.
These biomaterials are biocompatible and tunable.
They show promise for controlled drug release.
They can mimic the extracellular matrix for tissue engineering.

Conclusions:

pH-responsive self-assembling peptide biomaterials are versatile for drug delivery and tissue engineering.
Further development is needed to address future challenges.
These platforms offer significant potential for advanced biomedical applications.