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Neurosurgical Study Design: Past and Future.

Zoher Ghogawala1, Fred G Barker1, Sepideh Amin-Hanjani1

  • 1Department of Neurosurgery, Lahey Hospital and Medical Center, Burlington, Massachusetts, USA.

World Neurosurgery
|May 4, 2022
PubMed
Summary

Neurosurgical clinical trials are increasingly sophisticated. This review examines past prospective clinical trials, identifying barriers and successes to improve future neurosurgical practice.

Keywords:
Adaptive clinical trialClinical equipoiseClinical trialComparative effectivenessOutcome studiesProspective studiesRandomized controlled trial

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Area of Science:

  • Neurosurgery
  • Clinical Trials
  • Medical Research

Background:

  • Neurosurgical care historically evolved from case series and retrospective studies.
  • Prospective clinical trials are crucial for advancing neurosurgical practice.
  • The number and sophistication of neurosurgical clinical trials are growing.

Purpose of the Study:

  • To review the current landscape of prospective clinical trials in neurosurgery.
  • To identify barriers, successes, and failures in neurosurgical clinical trials.
  • To provide recommendations for improving future neurosurgical clinical trial design and execution.

Main Methods:

  • Focused exclusively on prospective clinical trials in neurosurgery.
  • Reviewed existing literature on neurosurgical clinical trials.
  • Analyzed barriers, successes, and failures.

Main Results:

  • Neurosurgical clinical trials are becoming more complex.
  • Past trials have faced various challenges but also yielded successes.
  • Understanding these outcomes is vital for progress.

Conclusions:

  • There is an urgent need to analyze past neurosurgical clinical trials.
  • Improvements in trial design and execution are necessary.
  • This review offers insights for advancing neurosurgical practice through better clinical trials.