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Updated: Sep 24, 2025
Author Spotlight: Understanding Age-Related Macular Degeneration Pathophysiology with QAF Workflow
Published on: May 26, 2023
Comparison of brain-derived neurotrophic factor among subtypes of exudative age-related macular degeneration
Keon Woo Park1, Jung Yeon Joo2, Seong Taeck Kim1
1Department of Ophthalmology, School of Medicine, Chosun University, Gwang-ju, Republic of Korea.
Purpose:
To compare the levels of brain-derived neurotrophic factor (BDNF) in serum and aqueous humor (AH) in eyes with typical neovascular age-related macular degeneration (tAMD), polypoidal choroidal vasculopathy (PCV), and retinal angiomatous proliferation (RAP).
Methods:
This prospective study included 20 patients with tAMD, 20 patients with PCV, 20 patients with RAP, and 20 healthy controls. BDNF levels in the serum and AH were assessed using enzyme-linked immunosorbent assay.
Results:
Serum and AH BDNF levels were significantly lower in the age-related macular degeneration groups (tAMD, PCV, and RAP) than in the control group (p < 0.05). There was no significant difference in the mean BDNF levels in the serum and AH among the different nAMD subtypes (p = 0.538).
Conclusions:
We confirmed that serum and AH BDNF levels were independent of the nAMD subtype.
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