Syncope: Diagnostic Yield of Various Clinical Investigations

The present study was designed to evaluate the clinical profile of patients with syncope and the usefulness of various tests to reach a diagnosis of syncope and its etiology.

This was a cross-sectional, observational study that enrolled 90 consecutive patients (aged ≥ 12 years) who presented with syncope. Detailed information was obtained from each enrolled patient on history and physical examination. All patients underwent electrocardiography (ECG) and echocardiographic examination. Other specific tests were also performed based on the findings from medical history, physical examination, ECG, and echocardiography findings.

Among 90 patients with syncope, 45% were males, and age distribution showed a bimodal distribution with two peaks. A total of 67% and 5% of patients had past history of syncope and injury due to syncope, respectively. Of the patients, 38% underwent Holter monitoring, 79 (87%) underwent head-up tilt table test (HUTT) test, 8% underwent treadmill test, 36% underwent CT/MRI of the brain, 25% underwent electroencephalography, 40% underwent carotid sinus massage, 7% underwent coronary angiography, 3% underwent electrophysiological study, and 3% of patients underwent carotid Doppler ultrasound. The commonly noted syncope was vasovagal/neutrally mediated syncope (68%). However, the etiology of syncope could not be determined in six (7%) patients.

This study concluded that the initial evaluation of patients with syncope should focus on history, physical examination, and ECG examination. Information obtained from such basic evaluations should be used to guide the selection of further high yield tests to reduce the cost of evaluation and for appropriate workup for the diagnosis of syncope.