Challenges of implementing the Paediatric Surviving Sepsis Campaign International Guidelines 2020 in resource-limited...

Area of Science:

• Pediatrics
• Infectious Diseases
• Global Health

Background:

• The 2020 Surviving Sepsis Campaign guidelines offer sepsis management recommendations for global pediatric care.
• Resource-limited settings (RLS) present unique challenges and disease patterns in pediatric sepsis management.
• Practitioners in RLS face difficulties implementing international guidelines due to resource constraints.

Purpose of the Study:

• To reflect on the implementation challenges of international sepsis guidelines in resource-limited settings (RLS) based on collective experience.
• To highlight the urgent need for RLS-specific evidence on feasible and effective sepsis and septic shock management in children.

Main Methods:

• Qualitative reflection based on collective clinical experience from resource-limited settings.
• Analysis of challenges encountered in applying international pediatric sepsis guidelines in diverse global contexts.

Main Results:

• International guidelines for pediatric sepsis management pose significant implementation hurdles in resource-limited settings.
• Disease patterns and resource availability in RLS necessitate context-specific approaches to sepsis care.
• A gap exists in evidence-based, feasible management strategies for pediatric sepsis and septic shock originating from RLS.

Conclusions:

• Current international pediatric sepsis guidelines require adaptation for resource-limited settings.
• Future guidelines should incorporate evidence from RLS to ensure effective and feasible sepsis management for all children.
• Further research focusing on RLS is crucial for advancing global pediatric sepsis care.