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Related Concept Videos

Protein-protein Interfaces02:04

Protein-protein Interfaces

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Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...
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Protein Networks02:26

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An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
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Ligand Binding Sites02:40

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Proteins are dynamic macromolecules that carry out a wide variety of essential processes; however, the activities of most proteins depend on their interactions with other molecules or ions, known as ligands.
Protein-ligand interactions are quite specific; even though numerous potential ligands surround a cellular protein at any given time, only a particular ligand can bind to that protein. Moreover, a ligand binds only to a dedicated area on the surface of the protein, known as the...
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Related Experiment Video

Updated: Sep 24, 2025

Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions
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IMEx Databases: Displaying Molecular Interactions into a Single, Standards-Compliant Dataset.

Pablo Porras1, Sandra Orchard1, Luana Licata2

  • 1European Bioinformatics Institute (EMBL-EBI), European Molecular Biology Laboratory, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, UK.

Methods in Molecular Biology (Clifton, N.J.)
|May 4, 2022
PubMed
Summary
This summary is machine-generated.

Molecular interaction databases organize experimental data for network analysis and pathway investigation. The IMEx Consortium provides high-quality, integrated molecular interaction data for researchers.

Keywords:
BioinformaticsControlled vocabularyDatabasesManual curationMolecular interaction data standardsMolecular interactions

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Area of Science:

  • Biochemistry
  • Bioinformatics
  • Systems Biology

Background:

  • Molecular interaction databases are crucial for organizing and analyzing experimental data from scientific literature.
  • Such data enables network analysis, protein function prediction, and cellular pathway investigation.

Purpose of the Study:

  • To provide an overview of publicly available molecular interaction databases.
  • To focus on the International Molecular Exchange (IMEx) Consortium, its curation policies, and data standards.
  • To detail the achievements, data types, and utilization of IMEx databases over 15 years.

Main Methods:

  • Review of publicly available molecular interaction databases.
  • Focus on IMEx Consortium members, their curation models, and data standards.
  • Description of data types and community utilization strategies.

Main Results:

  • IMEx databases curate molecular interaction data with high caliber, detailed curation models, and rich metadata.
  • Common curation rules and harmonized standards are employed.
  • The IMEx Consortium offers integrated, non-redundant, open-access molecular interaction data.

Conclusions:

  • IMEx databases provide a valuable, high-quality resource for molecular interaction data.
  • Standardized curation and data formats enhance data utility for the research community.
  • The IMEx Consortium successfully integrates diverse molecular interaction data into a cohesive dataset.