Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Neural and behavioral dynamics of acute fentanyl administration and implications for hazard assessment of novel synthetic opioids in larval zebrafish.

Pharmacological research·2026
Same author

Behavioral test batteries in zebrafish: methodological variability, experimental design, and implications for neurobehavioral research.

Reviews in the neurosciences·2026
Same author

Reinventing amlodipine.

The Journal of pharmacology and experimental therapeutics·2026
Same author

Para-chlorophenylalanine induces multidimensional affective-like behaviors in adult zebrafish.

Pharmacology, biochemistry, and behavior·2026
Same author

Fentanyl and alcohol co-exposure induce robust, sustained hyperlocomotion and neural circuit disruption in larval zebrafish.

Progress in neuro-psychopharmacology & biological psychiatry·2026
Same author

A larval zebrafish assay of the potency of sensory irritants correlates well with human TRPA1 activation and irritancy data.

Neurotoxicology·2026

Related Experiment Video

Updated: Sep 24, 2025

In Vivo Modeling of the Morbid Human Genome using Danio rerio
12:31

In Vivo Modeling of the Morbid Human Genome using Danio rerio

Published on: August 24, 2013

20.8K

Modelling ADHD-Like Phenotypes in Zebrafish.

Barbara D Fontana1, William H J Norton2,3, Matthew O Parker4

  • 1Brain and Behaviour Laboratory, School of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth, UK.

Current Topics in Behavioral Neurosciences
|May 4, 2022
PubMed
Summary
This summary is machine-generated.

Zebrafish offer valuable insights into attention-deficit/hyperactivity disorder (ADHD) by modeling conserved behaviors like attention and impulsivity. This review explores zebrafish models for accelerating new ADHD drug discovery.

Keywords:
ADHDAggressionAlternative modelsAnxietyAttentionHyperactivityImpulsivitySocial behaviorZebrafish

More Related Videos

Modeling Fetal Alcohol Spectrum Disorders in Zebrafish to Characterize the Impact of an Adverse Embryonic Environment on Adult Social Behavior
04:58

Modeling Fetal Alcohol Spectrum Disorders in Zebrafish to Characterize the Impact of an Adverse Embryonic Environment on Adult Social Behavior

Published on: February 9, 2024

434
Behavioral And Physiological Analysis In A Zebrafish Model Of Epilepsy
08:26

Behavioral And Physiological Analysis In A Zebrafish Model Of Epilepsy

Published on: October 19, 2021

5.8K

Related Experiment Videos

Last Updated: Sep 24, 2025

In Vivo Modeling of the Morbid Human Genome using Danio rerio
12:31

In Vivo Modeling of the Morbid Human Genome using Danio rerio

Published on: August 24, 2013

20.8K
Modeling Fetal Alcohol Spectrum Disorders in Zebrafish to Characterize the Impact of an Adverse Embryonic Environment on Adult Social Behavior
04:58

Modeling Fetal Alcohol Spectrum Disorders in Zebrafish to Characterize the Impact of an Adverse Embryonic Environment on Adult Social Behavior

Published on: February 9, 2024

434
Behavioral And Physiological Analysis In A Zebrafish Model Of Epilepsy
08:26

Behavioral And Physiological Analysis In A Zebrafish Model Of Epilepsy

Published on: October 19, 2021

5.8K

Area of Science:

  • Neuroscience and behavioral research
  • Comparative psychology and evolutionary biology

Background:

  • Human psychiatric disorders, such as ADHD, are complex and can be studied through conserved evolutionary patterns in behavior.
  • Multidomain behaviors like locomotion, attention, and impulsivity are key areas of investigation.

Purpose of the Study:

  • To discuss the advantages and challenges of using zebrafish (Danio rerio) to model ADHD-like phenotypes.
  • To review current ADHD studies in zebrafish and their potential for accelerating drug discovery.

Main Methods:

  • Utilizing zebrafish as a vertebrate model species widely employed in neuroscience.
  • Employing multiple behavioral tasks to model core ADHD symptoms and comorbidities.
  • Critical review of existing zebrafish ADHD research.

Main Results:

  • Zebrafish exhibit conserved evolutionary patterns relevant to ADHD-related behaviors.
  • Multiple behavioral assays can effectively model ADHD symptoms and associated conditions in zebrafish.
  • Zebrafish present a viable model for studying ADHD and testing potential treatments.

Conclusions:

  • Zebrafish provide a powerful model for understanding the neurobiological underpinnings of ADHD.
  • This model system holds significant promise for the development of novel therapeutic interventions for ADHD.