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Anhedonia in Nicotine Dependence.

David G Gilbert1, Bryant M Stone2

  • 1School of Psychological and Social Sciences, Southern Illinois University-Carbondale, Carbondale, IL, USA. dgilbert@siu.edu.

Current Topics in Behavioral Neurosciences
|May 4, 2022
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Summary

Anhedonia increases smoking risk, and nicotine can alleviate anhedonia. This review integrates the Research Domain Criteria (RDoC) and STAR model to explain nicotine

Keywords:
AnhedoniaNicotine dependenceRDOCSTAR modelSmokingState-dependent

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Area of Science:

  • Neuroscience and Psychology
  • Behavioral Science

Background:

  • Trait anhedonia is linked to increased smoking initiation.
  • Nicotine may alleviate anhedonic states, but relationships with nicotine dependence are complex.
  • Individual and situational factors can moderate these associations.

Purpose of the Study:

  • To critically review the literature on anhedonia and nicotine dependence.
  • To examine acute nicotine effects through the RDoC Positive Valence Systems and STAR model.
  • To propose a revised STAR model integrating RDoC criteria.

Main Methods:

  • Literature review and theoretical integration.
  • Analysis of subjective, behavioral, and brain indices of nicotine effects.
  • Application of the Research Domain Criteria (RDoC) and Situation x Trait Affective Response (STAR) model.

Main Results:

  • Nicotine's effects on hedonic processes vary across RDoC Positive Valence Systems.
  • A revised STAR model incorporates RDoC systems.
  • Nicotine's effects are maximal during suboptimal cognitive functioning and high reward sensitivity, with low situational cue salience.

Conclusions:

  • The RDoC framework and STAR model offer valuable perspectives for understanding anhedonia and nicotine dependence.
  • A revised STAR model provides a nuanced understanding of nicotine's effects on hedonic processes.
  • Further research integrating these models can guide clinical innovation for smoking cessation and related disorders.